Di-tert-butyl dicarbonate

ʻO ka wehewehe pōkole:

Inoa mea kūʻai:Di-tert-butyl dicarbonate

Nā huaʻōlelo like:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, paʻa/wai

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Māhele Huahana:ʻO nā lāʻau lapaʻau waena; Hoʻomaka i nā mea ʻala a me nā mea waena; nā mea hoʻokalakupua ʻo amino; nā mea ola; nā mea hoʻopalekana-n; biochemistry; peptide synthesis; pale a me nā mea hoʻoponopono derivatization (no ka synthesis); nā mea hoʻomalu pale (peptide synthesis); Moʻo ʻakika Boc-Amino; Nā mea hoʻoponopono like ʻole; DIBOC; 1H-Inden-1-ol; bc0001; 24424-99-5

Kōnae Mol:24424-99-5.mol

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Di-tert-butyl dicarbonate Na Waiwai Kemika

Lae hehee	23 °C (māmā)
Lae paila	56-57 °C/0.5 mmHg (māmā)
mānoanoa	0.95 g/mL ma 25 °C (kukui.)
kaomi mahu	3.85Pa ma 25 ℃
hōʻike hoʻopaʻa ʻana	n20/D 1.409(māmā)
Fp	99 °F
ka mahana mālama.	2-8°C
ʻano	Paʻa Kalikiano Heʻe Haʻahaʻa
kala kala	Keʻokeʻo
Kaumaha Kūikawā	0.950
Hiki i ka wai	Hiki ke hui me ka decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile a me dimethylformamide.Hiki ʻole me ka wai.
Pilikino	ʻAiʻoniʻoni
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 ma 25 ℃
ʻIkepili ʻikepili CAS	24424-99-5(Hōʻike Papaʻikepili CAS)
Pūnaehana Kakau Lapaʻau EPA	ʻAka Dicarbonic, bis(1,1-dimethylethyl) ester (24424-99-5)

ʻIke palekana

Nā Code Hazard	T+,T,F,Xi,F+
Nā ʻŌlelo Hoʻopilikia	11-19-26-36/37/38-43-10-40
Nā ʻōlelo palekana	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Kelemānia	3
RTECS	HT0230000
F	4.4-10-21
ʻO ka wela hoʻomāmā	460 °C
Nānā Hazard	Hiki i ke ahi/hoʻohuhū/ʻona loa
TSCA	ʻAe
HazardClass	6.1
Hui Pūʻulu	I
HS Code	29209010
Kaʻawaʻawa	LD50 ma ka waha i ka Lapiti: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

ʻO ka hoʻohana ʻana a me ka hoʻohana ʻana o Di-tert-butyl dicarbonate

Na Waiwai Kemika	ʻO ka Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) he kala ʻole i ke keʻokeʻo a hiki i nā kristal melemele, paʻa paʻa a i ʻole wai maʻemaʻe.Hehee ia a puni ka lumi wela (mp=23°C).ʻAʻole ia e decompose ma kēia a i ʻole ka wela iki aʻe.No ka laʻana, hoʻomaʻemaʻe maʻamau ia e ka distillation ma lalo o ke kaomi hoʻemi ʻia ma nā mahana a hiki i kahi o 65°C.Ma nā wela kiʻekiʻe e hoʻoheheʻe ʻia i isobutene, t-butyl alcohol a me carbon dioxide.
Hoʻohana	ʻO Di-tert-butyl dicarbonate (Boc2O) he mea hoʻohana nui ia no ka hoʻokomo ʻana i nā hui pale i ka peptide synthesis.He kuleana koʻikoʻi ia i ka hoʻomākaukau ʻana o 6-acetyl-1,2,3,4-tetrahydropyridine ma o ka hana ʻana me 2-piperidone.Hoʻohana ia ma ke ʻano he pūʻulu pale i hoʻohana ʻia i ka solid phase peptide synthesis.
Hoʻomākaukau	ʻO ka hoʻomākaukau ʻana i ka Di-tert-butyl dicarbonate penei: Ua hoʻohui ʻia ka wai paʻakai paʻakai monoester 2g o N, N-dimethylformamide, 1g pyridine, 1g o triethylamine, Hoʻoluʻu i -5 ~ 0 ° C, 60g diphosgene ua mālie. hoʻohui dropwise i loko o 1.5h dropwise hoʻohui ua piha, mehana i ka lumi wela (25 ° C), incubated no 2h, ka pane ua ae e ku ma hope o filtration, holoi organic solution.Hoʻomaloʻo ʻia me ka magnesium sulfate anhydrous, ua hoʻoheheʻe ʻia ka mea hoʻoheheʻe ma ke kaomi ʻana i ka lewa e hāʻawi i ka hua ʻai 65 ~ 70g.Ma hope o ka hoʻoluʻu a me ka crystallization, ua loaʻa ka 57-60g o di-tert-butyl dicarbonate i kahi hua o 60-63%.
Wehewehe	ChEBI: ʻO ka di-tert-butyl dicarbonate he acyclic carboxylic anhydride.He mea pili i ka waika dicarbonic.
Nā pane	ʻO ka hopena o nā aniline i hoʻololi ʻia me Boc2O i ke alo o kahi nui stoichiometric o 4-dimethylaminopyridine (DMAP) i loko o kahi mea hoʻoheheʻe inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) ma ka lumi wela e alakaʻi i ka aryl isocyanates i loko o ka nui o yie. min. Ua kipa hou ʻia ʻo Di-tert-butyl dicarbonate a me 4-(dimethylamino)pyridine.ʻO kā lākou hopena me nā amine a me nā waiʻona
Ka wehewehe nui	di-tert-butyl dicarbonate (Boc₂O) he reagent i hoʻohana nui ʻia no ka hoʻokomo ʻana i ka hui pale Boc i nā hana amine.Hoʻohana ʻia ʻo ia ma ke ʻano he mea hoʻoheheʻe wai i kekahi mau hopena kūlohelohe, ʻoi aku me nā waikawa carboxylic, kekahi mau pūʻulu hydroxyl, a i ʻole me nā nitroalkanes mua.
Pilikia	He mea hoʻonāukiuki hiki ke hōʻeha nui i ka maka;Hiki ke hoʻoulu i ka ʻili;ʻona loa ma ka inhalation
ʻO ke ahi a me ka pahū	Hiki ke ahi
Na Hana Hoomaemae	E hoʻoheheʻe i ka ester ma ka hoʻomehana ʻana ma ~35o, a hoʻoheheʻe ʻia i loko o kahi ʻā.Inā hōʻike ʻo IR a me NMR (1810m 1765 cm-1, ma CCl4 1.50 singlet) i ka haumia loa, a laila holoi me ka nui like o ka H2O i loko o ka ʻakika citric e hoʻokaʻawale iki ka papa wai, e hōʻiliʻili i ka papa organik a maloʻo ma luna o MgSO4 anhydrous. a hoʻoheheʻe ʻia i loko o kahi ʻūhā.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] PALAPALA.